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J Infect. 2013 Nov;67(5):463-9. doi: 10.1016/j.jinf.2013.06.016. Epub 2013 Jul 16.

A population based study of the epidemiology of Herpes Zoster and its complications.

Author information

1
Maccabi Healthcare Services, Medical Division, Tel Aviv, Israel. Electronic address: weitzman_d@mac.org.il.

Abstract

OBJECTIVES:

To assess the incidence of Herpes Zoster (HZ) and its complications in the Israeli general population and specifically in immune-compromised individuals, and to identify risk factors for developing HZ and post-herpetic neuralgia (PHN).

METHODS:

A retrospective database search for newly diagnosed cases of HZ and of PHN during 2006-2010 was conducted using the comprehensive longitudinal database of Maccabi Health Services. Cox-proportional hazards models were used to assess associations between risk factors and HZ and PHN.

RESULTS:

During 2006-2010 there were 28,977 newly diagnosed cases of HZ and 1508 newly diagnosed cases of PHN. Incidence density rate of HZ was 3.46 per 1000 person-years in the total population and 12.8 per 1000 person-years in immune-compromised patients. HZ and PHN incidence increased sharply with age. 12.4% and 3.1% of elderly HZ patients (≥ 65 years) developed PHN or ophthalmic complications, respectively. In multivariable analyses, HZ and PHN were associated with female sex, higher socioeconomic status, diabetes mellitus, cancer history, and HIV treatment.

CONCLUSIONS:

Extrapolating to the entire Israeli population, we estimate over 24,000 new cases of HZ and 1250 new cases of PHN each year. Cost-effectiveness analysis should be performed to determine the threshold age for vaccination against HZ.

KEYWORDS:

Herpes Zoster; Incidence; Neuralgia; Postherpetic; Risk factors

PMID:
23872209
DOI:
10.1016/j.jinf.2013.06.016
[Indexed for MEDLINE]

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