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Biochem Biophys Res Commun. 2013 Aug 16;438(1):90-6. doi: 10.1016/j.bbrc.2013.07.031. Epub 2013 Jul 18.

miR-21 coordinates tumor growth and modulates KRIT1 levels.

Author information

1
Molecular Biotechnology Center, University of Torino, Torino, Italy.

Abstract

miR-21 is overexpressed in tumors and it displays oncogenic activity. Here, we show that expression of miR-21 in primary tumors anticorrelates with KRIT1/CCM1, an interacting partner of the Ras-like GTPase Rap1, involved in Cerebral Cavernous Malformations (CCM). We present evidences that miR-21 silences KRIT1 by targeting its mRNA 3'UTR and that this interaction is involved in tumor growth control. In fact, miR-21 over-expression or KRIT1 knock-down promote anchorage independent tumor cell growth compared to controls, whereas the opposite is observed when anti-miR-21 or KRIT1 overexpression are employed. Our findings suggest that miR-21 promotes tumor cell growth, at least in part, by down-modulating the potential tumor suppressor KRIT1.

KEYWORDS:

KRIT1; Tumor growth; miR-21

PMID:
23872064
PMCID:
PMC3750217
DOI:
10.1016/j.bbrc.2013.07.031
[Indexed for MEDLINE]
Free PMC Article
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