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Alzheimers Dement. 2014 Mar;10(2):162-70. doi: 10.1016/j.jalz.2013.04.507. Epub 2013 Jul 18.

Global brain hypoperfusion and oxygenation in amnestic mild cognitive impairment.

Author information

1
Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Dallas, TX, USA; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA; Department of Ultrasound Diagnostics, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.
2
Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Dallas, TX, USA; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
3
Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Dallas, TX, USA.
4
Department of Neurology and Neurotherapeutics and the Alzheimer's Disease Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.
5
Department of Neurology and Neurotherapeutics and the Alzheimer's Disease Center, University of Texas Southwestern Medical Center, Dallas, TX, USA; Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA.
6
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.
7
Center for Neuroscience and Regenerative Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
8
Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Dallas, TX, USA; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA; Department of Neurology and Neurotherapeutics and the Alzheimer's Disease Center, University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address: RongZhang@texashealth.org.

Abstract

BACKGROUND:

To determine if global brain hypoperfusion and oxygen hypometabolism occur in patients with amnestic mild cognitive impairment (aMCI).

METHODS:

Thirty-two aMCI and 21 normal subjects participated. Total cerebral blood flow (TCBF), cerebral metabolic rate of oxygen (CMRO2), and brain tissue volume were measured using color-coded duplex ultrasonography (CDUS), near-infrared spectroscopy (NIRS), and MRI. TCBF was normalized by total brain tissue volume (TBV) for group comparisons (nTCBF). Cerebrovascular resistance (CVR) was calculated as mean arterial pressure divided by TCBF.

RESULTS:

Reductions in nTCBF by 9%, CMRO2 by 11%, and an increase in CVR by 13% were observed in aMCI relative to normal subjects. No group differences in TBV were observed. nTCBF was correlated with CMRO2 in normal controls, but not in aMCI.

CONCLUSIONS:

Global brain hypoperfusion, oxygen hypometabolism, and neurovascular decoupling observed in aMCI suggest that changes in cerebral hemodynamics occur early at a prodromal stage of Alzheimer's disease, which can be assessed using low-cost and bedside-available CDUS and NIRS technology.

KEYWORDS:

Cerebral blood flow; Cerebral metabolic rate of oxygen; MRI; Mild cognitive impairment; Near-infrared spectroscopy; Ultrasonography

PMID:
23871763
PMCID:
PMC3859724
DOI:
10.1016/j.jalz.2013.04.507
[Indexed for MEDLINE]
Free PMC Article
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