Send to

Choose Destination
Brain Lang. 2013 Nov;127(2):145-56. doi: 10.1016/j.bandl.2013.05.018. Epub 2013 Jul 17.

Examining the value of lexical retrieval treatment in primary progressive aphasia: two positive cases.

Author information

Memory and Aging Center, Department of Neurology, University of California, 675 Nelson Rising Lane, Suite 190, San Francisco, CA 94158, United States; Communicative Disorders Program, Department of Special Education, San Francisco State University, 1600 Holloway Avenue, San Francisco, CA 94132, United States. Electronic address:


Individuals with primary progressive aphasia (PPA) suffer a gradual decline in communication ability as a result of neurodegenerative disease. Language treatment shows promise as a means of addressing these difficulties but much remains to be learned with regard to the potential value of treatment across variants and stages of the disorder. We present two cases, one with semantic variant of PPA and the other with logopenic PPA, each of whom underwent treatment that was unique in its focus on training self-cueing strategies to engage residual language skills. Despite differing language profiles and levels of aphasia severity, each individual benefited from treatment and showed maintenance of gains as well as generalization to untrained lexical items. These cases highlight the potential for treatment to capitalize on spared cognitive and neural systems in individuals with PPA, improving current language function as well as potentially preserving targeted skills in the face of disease progression.


Lexical retrieval; Logopenic variant; Naming; Primary progressive aphasia; Rehabilitation; Semantic dementia; Treatment

[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center