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Neuron. 2013 Aug 7;79(3):530-40. doi: 10.1016/j.neuron.2013.06.006. Epub 2013 Jul 18.

Nicotine decreases ethanol-induced dopamine signaling and increases self-administration via stress hormones.

Author information

1
Center on Addiction, Learning, Memory, Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA.

Abstract

Tobacco smoking is a well-known risk factor for subsequent alcohol abuse, but the neural events underlying this risk remain largely unknown. Alcohol and nicotine reinforcement involve common neural circuitry, including the mesolimbic dopamine system. We demonstrate in rodents that pre-exposure to nicotine increases alcohol self-administration and decreases alcohol-induced dopamine responses. The blunted dopamine response was due to increased inhibitory synaptic transmission onto dopamine neurons. Blocking stress hormone receptors prior to nicotine exposure prevented all interactions with alcohol that we measured, including the increased inhibition onto dopamine neurons, the decreased dopamine responses, and the increased alcohol self-administration. These results indicate that nicotine recruits neuroendocrine systems to influence neurotransmission and behavior associated with alcohol reinforcement.

PMID:
23871233
PMCID:
PMC3755901
DOI:
10.1016/j.neuron.2013.06.006
[Indexed for MEDLINE]
Free PMC Article

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