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J Affect Disord. 2013 Nov;151(2):791-4. doi: 10.1016/j.jad.2013.06.053. Epub 2013 Jul 18.

Affect recognition across manic and euthymic phases of bipolar disorder in Han-Chinese patients.

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Far Eastern Memorial Hospital, Taipei, Taiwan; Health Service and Population Research Department, Institute of Psychiatry, King's College London, London, United Kingdom; Department of Public Health, School of Medicine, National Yang-Ming University, Taipei, Taiwan.


Patients with bipolar disorder (BD) have affect recognition deficits. Whether affect recognition deficits constitute a state or trait marker of BD has great etiopathological significance. The current study aims to explore the interrelationships between affect recognition and basic neurocognitive functions for patients with BD across different mood states, using the Diagnostic Analysis of Non-Verbal Accuracy-2, Taiwanese version (DANVA-2-TW) as the index measure for affect recognition. To our knowledge, this is the first study examining affect recognition deficits of BPD across mood states in the Han Chinese population. Twenty-nine manic patients, 16 remitted patients with BD, and 40 control subjects are included in the study. Distinct association patterns between affect recognition and neurocognitive functions are demonstrated for patients with BD and control subjects, implicating alternations in emotion associated neurocognitive processing. Compared to control subjects, manic patients but not remitted subjects perform significantly worse in the recognition of negative emotions as a whole and specifically anger, after adjusting for differences in general intellectual ability and basic neurocognitive functions. Affect recognition deficit may be a relatively independent impairment in BD rather than consequences arising from deficits in other basic neurocognition. The impairments of manic patients in the recognition of negative emotions, specifically anger, may further our understanding of core clinical psychopathology of BD and have implications in treating bipolar patients across distinct mood phases.


Affect recognition; Anger; Bipolar disorder; Emotion processing; Neurocognition

[Indexed for MEDLINE]

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