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Trends Biochem Sci. 2013 Sep;38(9):453-60. doi: 10.1016/j.tibs.2013.06.008. Epub 2013 Jul 16.

Emerging roles of E3 ubiquitin ligases in autophagy.

Author information

1
Signal Transduction Program, Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, USA. kuangersh@mail.sysu.edu.cn

Abstract

Autophagy is an evolutionarily conserved intracellular catabolic process that delivers cytoplasmic components to lysosomes for degradation and recycling. Although originally considered to be a non-selective pathway, it is now recognized that autophagy is involved in selective processes, including the turnover of organelles, removal of protein aggregates, and elimination of intracellular pathogens. This specificity implies that cargo recognition and processing by the autophagy machinery are tightly regulated processes. In support of this, various forms of post-translational modification have been implicated in the regulation of autophagy, one of which is the ubiquitin-proteasome system. Here we review current understanding of the role of ubiquitylation in the control of autophagy.

KEYWORDS:

RNF5; autophagy; parkin; proteasome; ubiquitin ligase

PMID:
23870665
PMCID:
PMC3771342
DOI:
10.1016/j.tibs.2013.06.008
[Indexed for MEDLINE]
Free PMC Article

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