Revisiting caspase-11 function in host defense

Cell Host Microbe. 2013 Jul 17;14(1):9-14. doi: 10.1016/j.chom.2013.06.009.

Abstract

Proinflammatory caspases play important roles in innate immunity. Much attention has focused on caspase-1, which acts to eliminate pathogens by obliterating their replicative niches as well as alerting the host to their presence. Now, emerging data have shed light on the lesser-studied proinflammatory caspase-11 in the combat between host and pathogens. Using the new tools available, researchers are further elucidating the mechanisms by which caspase-11 contributes to host defense. Here, we review the emerging understanding of caspase-11 functions and the mechanisms of activation and discuss the implications for human disease.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Caspases / chemistry
  • Caspases / genetics
  • Caspases / immunology*
  • Caspases, Initiator / chemistry
  • Caspases, Initiator / genetics
  • Caspases, Initiator / immunology
  • Host-Pathogen Interactions
  • Humans
  • Immunity, Innate*
  • Inflammation / immunology

Substances

  • CASP4 protein, human
  • CASP5 protein, human
  • Casp4 protein, mouse
  • Caspases
  • Caspases, Initiator