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J Nanobiotechnology. 2013 Jul 19;11:26. doi: 10.1186/1477-3155-11-26.

Interaction of nanoparticles with proteins: relation to bio-reactivity of the nanoparticle.

Author information

1
Centre for Biodiscovery and Molecular Development of Therapeutics, School of Pharmacy and Molecular Science, James Cook University, Townsville, Queensland, Australia.

Abstract

Interaction of nanoparticles with proteins is the basis of nanoparticle bio-reactivity. This interaction gives rise to the formation of a dynamic nanoparticle-protein corona. The protein corona may influence cellular uptake, inflammation, accumulation, degradation and clearance of the nanoparticles. Furthermore, the nanoparticle surface can induce conformational changes in adsorbed protein molecules which may affect the overall bio-reactivity of the nanoparticle. In depth understanding of such interactions can be directed towards generating bio-compatible nanomaterials with controlled surface characteristics in a biological environment. The main aim of this review is to summarise current knowledge on factors that influence nanoparticle-protein interactions and their implications on cellular uptake.

PMID:
23870291
PMCID:
PMC3720198
DOI:
10.1186/1477-3155-11-26
[Indexed for MEDLINE]
Free PMC Article

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