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Trends Genet. 2013 Nov;29(11):621-9. doi: 10.1016/j.tig.2013.06.006. Epub 2013 Jul 16.

Balancing chromatin remodeling and histone modifications in transcription.

Author information

1
University of California, San Diego, Division of Biological Sciences, Molecular Biology, UCSD Moores Cancer Center, 9500 Gilman Drive, La Jolla, CA 92093-0347, USA.

Abstract

Chromatin remodelers use the energy of ATP hydrolysis to reposition or evict nucleosomes or to replace canonical histones with histone variants. By regulating nucleosome dynamics, remodelers gate access to the underlying DNA for replication, repair, and transcription. Nucleosomes are subject to extensive post-translational modifications that can recruit regulatory proteins or alter the local chromatin structure. Just as extensive crosstalk has been observed between different histone post-translational modifications, there is growing evidence for both coordinated and antagonistic functional relations between nucleosome remodeling and modifying machineries. Defining the combined functions of the complexes that alter nucleosome interactions, position, and stability is key to understanding processes that require access to DNA, particularly with growing appreciation of their contributions to human health and disease. Here, we highlight recent advances in the interactions between histone modifications and the imitation-switch (ISWI) and chromodomain helicase DNA-binding protein 1 (CHD1) chromatin remodelers from studies in budding yeast, fission yeast, flies, and mammalian cells, with a focus on yeast.

KEYWORDS:

Chd1; ISWI; chromatin; histone modification; nucleosome; yeast

PMID:
23870137
PMCID:
PMC4408995
DOI:
10.1016/j.tig.2013.06.006
[Indexed for MEDLINE]
Free PMC Article

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