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Ceska Gynekol. 2013 Jun;78(3):247-51.

[The incidence of latent asymptomatic celiac disease in women with decreased fertility].

[Article in Czech]

Author information

1
Ústav histologie a embryologie LF UK, Plzeň.

Abstract

OBJECTIVE:

To determine whether patients with recurrent spontaneous abortions and IVF suffer from latent celiac disease.

DESIGN:

Perspective study.

SETTINGS:

Department of Gynecology and Obstetrics and Faculty Hospital, Charles University, Pilsen.

MATERIAL AND METHODS:

Sera from 442 infertile patients aged 23-47 years and 86 healthy fertile controls aged 22-38 years were examined by commercial ELISA sets for the presence (absence) of antibodies against gliadin IgG, IgA and tissue transglutaminase in IgG and IgA.

RESULTS:

We found a statistically significant difference between the control group and patients with decreased fertility. They have a positive values in anti-tissue transglutaminase IgA (p = 0.0096). Frequent, very low positive reaction of antigliadin IgG was also found in the control group of women.

CONCLUSION:

Patients with unexplained repeated miscarriages and repeated unsuccessful IVF with IgA positive tissue transglutaminase have new complement of other tests for autoimmunity and examination of a total IgA, and gastroenterological examination. Eleven patients with significant positive anti-tissue transglutaminase IgA were successfully conceived only under strict gluten-free diet.

PMID:
23869830
[Indexed for MEDLINE]
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