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J Asian Nat Prod Res. 2013;15(10):1100-6. doi: 10.1080/10286020.2013.818660. Epub 2013 Jul 22.

Two new terpenoid benzoates with antitumor activity from the roots of Ferula dissecta.

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1
a Department of New Drug , Institute of Frontier Medical Sciences, Jilin University , Changchun , 130021 , China.

Abstract

Two new sesquiterpene benzoates, syreiteate A (1) and syreiteate B (2), were isolated from the roots of Ferula dissecta (Ledeb.) Ledeb. Their structures were elucidated by extensive spectroscopic methods including 1D ((1)H and (13)C) NMR, 2D (HSQC, HMBC, DQF-COSY, and NOESY) NMR, and ESI-TOF-MS. Their configurations were determined on the basis of the analysis of the coupling constants, NOESY correlations, and circular dichroism spectrum. Compounds 1 and 2 showed potent growth inhibitory activity against cervical cancer HeLa cell line with the IC50 values of 13.2 and 19.3 μM, respectively.

PMID:
23869569
DOI:
10.1080/10286020.2013.818660
[Indexed for MEDLINE]
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