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Indian J Endocrinol Metab. 2013 May;17(3):509-13. doi: 10.4103/2230-8210.111669.

Feminizing adrenal tumors: Our experience about three cases.

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Department of Endocrine, and Metabolic Diseases, Bab El Oued Hospital, 5boulevard Said Touati, Algiers, Algeria.

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  • Indian J Endocrinol Metab. 2013 Nov;17(6):986. Farida, Chentli [corrected to Chentli, Farida]; Ilyes, Bekkaye [corrected to Bekkaye, Ilyes]; Smina, Yahiaoui [corrected to Yahiaoui, Smina]; Sabrina, Souidi [corrected to Souidi, Sabrina]; Soumeya, Fedala Nora [corrected to Fedala, Nora Soumeya]; Said, Azzoug [corrected to Azzoug, Said].


Feminizing adrenal tumors (FATs) are very rare as they account for less than 2% of all the adrenal neoplasms. Their prognosis is deemed to be very poor. We aimed to present a mono centre (adult and pediatric) experience over a long period of time (January 1980 to Jun 2012). During the study period, we observed only three cases in men aged 22 (2 cases) and 45 (1 case). They all consulted for a painful gynecomastia, decreased libido and impotency. Estradiol was high in two cases at presentation, and after a relapsing tumor in the third one. All had big adrenal tumors (5.9, 6, and 17 cm), and a mixed secretion composed by high estradiol and cortisol. The pathological study argued for malignancy in two cases. But, only one had diffuse metastasis and died 4 years after diagnosis; the others diagnosed one and three years ago are still alive without any metastasis or relapsing.


Adrenal; feminizing tumors; gynecomastia; hypogonadism

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