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Ann Neurol. 2013 Oct;74(4):622-6. doi: 10.1002/ana.23973. Epub 2013 Sep 16.

JC virus granule cell neuronopathy and GCN-IRIS under natalizumab treatment.

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Neuroimmunology and Multiple Sclerosis Research Section, Department of Neurology, University Hospital Zurich, Zurich; Department of Neurology, University Hospital Zurich, Zurich.


Progressive multifocal leukoencephalopathy is the most common clinical presentation of JC virus (JCV)-associated central nervous system (CNS) disease and has emerged as a major safety concern in multiple sclerosis patients treated with the monoclonal antibody natalizumab. Here we report clinical, radiological, and histological findings of a case of cerebellar granule cell neuronopathy (GCN), a JCV-associated CNS disease, so far unreported amongst patients treated with natalizumab. GCN should be considered as a JCV CNS manifestation in patients with newly developed, progressive cerebellar signs under natalizumab treatment, especially in cases where cerebellar atrophy can be visualized by magnetic resonance imaging.

[Indexed for MEDLINE]

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