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Curr Opin Neurobiol. 2013 Dec;23(6):1057-64. doi: 10.1016/j.conb.2013.06.006. Epub 2013 Jul 15.

'Sealing off the CNS': cellular and molecular regulation of blood-brain barriergenesis.

Author information

1
Department of Pediatrics, Section of Developmental Biology, University of Colorado, Denver, Aurora, CO 80045, United States. Electronic address: Julie.Siegenthaler@ucdenver.edu.

Abstract

From their initial ingression into the neural tube to the established, adult vascular plexus, blood vessels within the CNS are truly unique. Covered by a virtually continuous layer of perivascular cells and astrocytic endfeet and connected by specialized cell-cell junctional contacts, mature CNS blood vessels simultaneously provide nutritive blood flow and protect the neural milieu from potentially disruptive or harmful molecules and cells flowing through the vessel lumen. In this review we will discuss how the CNS vasculature acquires blood-brain barrier (BBB) properties with a specific focus on recent work identifying the cell types and molecular pathways that orchestrate barriergenesis.

PMID:
23867075
PMCID:
PMC4061913
DOI:
10.1016/j.conb.2013.06.006
[Indexed for MEDLINE]
Free PMC Article
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