Format

Send to

Choose Destination
See comment in PubMed Commons below
Immunology. 2013 Nov;140(3):281-7. doi: 10.1111/imm.12153.

Group 2 innate lymphoid cells in lung inflammation.

Author information

1
Department of Pulmonary Medicine, Erasmus MC Rotterdam, Rotterdam, the Netherlands.

Abstract

Although allergic asthma is a heterogeneous disease, allergen-specific T helper 2 (Th2) cells producing the key cytokines involved in type 2 inflammation, interleukin-4 (IL-4), IL-5 and IL-13, are thought to play a major role in asthma pathogenesis. This model is challenged by the recent discovery of group 2 innate lymphoid cells (ILC2) that represent a critical innate source of type 2 cytokines. These ILC2 are activated by epithelial cell-derived cytokines, including IL-25 and IL-33, which have been implicated in the initiation of asthma. In this review, we will discuss recent studies supporting a significant role for ILC2 in lung inflammation, with special attention to allergen-induced asthma.

KEYWORDS:

T cells; asthma; innate immunity; lung immunology disease

PMID:
23866009
PMCID:
PMC3800433
DOI:
10.1111/imm.12153
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley Icon for PubMed Central
    Loading ...
    Support Center