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Clin Dev Immunol. 2013;2013:264124. doi: 10.1155/2013/264124. Epub 2013 Jun 25.

Microglia and macrophages in malignant gliomas: recent discoveries and implications for promising therapies.

Author information

1
Laboratório de Morfogênese Celular, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.

Abstract

Malignant gliomas are the most common primary brain tumors. Their deadliest manifestation, glioblastoma multiforme (GBM), accounts for 15% of all primary brain tumors and is associated with a median survival of only 15 months even after multimodal therapy. There is substantial presence of microglia and macrophages within and surrounding brain tumors. These immune cells acquire an alternatively activated phenotype with potent tumor-tropic functions that contribute to glioma growth and invasion. In this review, we briefly summarize recent data that has been reported on the interaction of microglia/macrophages with brain tumors and discuss potential application of these findings to the development of future antiglioma therapies.

PMID:
23864876
PMCID:
PMC3707269
DOI:
10.1155/2013/264124
[Indexed for MEDLINE]
Free PMC Article

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