Format

Send to

Choose Destination
J Clin Endocrinol Metab. 2013 Sep;98(9):E1483-90. doi: 10.1210/jc.2013-1698. Epub 2013 Jul 17.

Vitamin D status is associated with functional limitations and functional decline in older individuals.

Author information

1
Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Center, 1081 BT Amsterdam, The Netherlands.

Abstract

CONTEXT:

Vitamin D is known to influence muscle health. A reduction in muscle mass increases the risk of functional limitations among older individuals.

OBJECTIVE:

The aim of this study was to examine the relationship between vitamin D status and functional limitations.

DESIGN, SETTING, AND PARTICIPANTS:

Two independent cohorts of the Longitudinal Aging Study Amsterdam were used. Participants were aged 65 to 88 years (older cohort, n = 1237; baseline 1995) and 55 to 65 years (younger cohort, n = 725; baseline 2002).

MAIN OUTCOME MEASURES:

Questions on the ability and degree of difficulty to perform 6 functions of daily life were asked.

RESULTS:

Of the participants, 56% in the older cohort and 30% in the younger cohort had ≥1 limitation. Vitamin D deficiency (25-hydroxyvitamin D level of <20 ng/mL) compared with the value in the reference group (>30 ng/mL) was related to the presence of functional limitations at baseline (odds ratio [OR] = 1.7; 95% confidence interval [CI], 1.2-2.5 and OR = 2.2; 95% CI 1.3-3.7 for the older and younger cohorts, respectively). In the older cohort, vitamin D deficiency was associated with an increase in limitations at 3 years (OR = 2.0; 95% CI, 1.1-3.5), whereas vitamin D deficiency in the younger cohort was associated with an increase in limitations at 6 years (OR = 3.3; 95% CI, 1.1-10.1). Analyses were adjusted for confounders.

CONCLUSION:

Vitamin D status is associated with functional limitations cross-sectionally and longitudinally in individuals aged 55 to 65 years and those 65 years and older. The possible association of vitamin D with functional limitations is present after a shorter follow-up time in the oldest age group compared with the younger age group.

PMID:
23864700
DOI:
10.1210/jc.2013-1698
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Silverchair Information Systems
Loading ...
Support Center