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J Virol. 2013 Oct;87(19):10884-8. doi: 10.1128/JVI.01016-13. Epub 2013 Jul 17.

Mammalian adaptation in the PB2 gene of avian H5N1 influenza virus.

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1
Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, Maryland, USA.

Abstract

The substitution of glutamic acid (E) for lysine (K) at position 627 of the PB2 protein of avian H5N1 viruses has been identified as a virulence and host range determinant for infection of mammals. Here, we report that the E-to-K host-adaptive mutation in the PB2 gene appeared from day 4 and 5 along the respiratory tracts of mice and was complete by day 6 postinoculation. This mutation correlated with efficient replication of the virus in mice.

PMID:
23864613
PMCID:
PMC3807384
DOI:
10.1128/JVI.01016-13
[Indexed for MEDLINE]
Free PMC Article
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