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J Clin Invest. 2013 Jul;123(7):2773-4. doi: 10.1172/JCI69344. Epub 2013 Jul 1.

Antiinflammatory effects of apoptotic cells.

Author information

1
Program in Cell Biology, Department of Pediatrics, National Jewish Health, Denver, Colorado, USA. hensonp@njhealth.org

Abstract

Apoptotic cells are rapidly phagocytosed by macrophages, a process that represents a critical step in tissue remodeling, immune responses, and the resolution of inflammation. In 1998, Peter Henson, Donna Bratton, and colleagues at National Jewish Health demonstrated that phagocytosis of apoptotic cells actively suppresses inflammation by inhibiting the production of inflammatory cytokines and inducing production of antiinflammatory factors, including TGF-β and prostaglandin E2. Here they discuss the evolving relationship among apoptosis, phagocytosis, and inflammation.

PMID:
23863635
PMCID:
PMC3696541
DOI:
10.1172/JCI69344
[Indexed for MEDLINE]
Free PMC Article

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