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J Clin Microbiol. 2013 Oct;51(10):3403-5. doi: 10.1128/JCM.01357-13. Epub 2013 Jul 17.

Evaluation of the BD Bactec MGIT 320 system for detection of mycobacteria and drug susceptibility testing of Mycobacterium tuberculosis.

Author information

1
Microbial Diseases Laboratory, DCDC, CID, California Department of Public Health, Richmond, California, USA.

Abstract

Two different laboratories evaluated growth and detection of mycobacteria and drug susceptibility testing of Mycobacterium tuberculosis by the BD Bactec MGIT 320 using the BD Bactec MGIT 960 (BD Diagnostics, Sparks, MD) as a reference method. Out of 359 processed sputum specimens for detection of mycobacteria, 99.7% were in agreement between the MGIT 320 and MGIT 960. Streptomycin (STR), isoniazid (INH), rifampin (RIF), ethambutol (EMB) (collectively known as SIRE), and pyrazinamide (PZA) drug susceptibility testing was performed on 89 clinical strains, prepared from both liquid and solid inocula. The results of SIRE and PZA were 100% reproducible between the two instruments tested at both laboratories.

PMID:
23863564
PMCID:
PMC3811643
DOI:
10.1128/JCM.01357-13
[Indexed for MEDLINE]
Free PMC Article

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