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Crit Care Med. 2013 Aug;41(8):2008-14. doi: 10.1097/CCM.0b013e31829a6eb4.

In silico modeling: methods and applications to trauma and sepsis.

Author information

1
Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA. vodovotzy@upmc.edu

Abstract

OBJECTIVES:

To familiarize clinicians with advances in computational disease modeling applied to trauma and sepsis.

DATA SOURCES:

PubMed search and review of relevant medical literature.

SUMMARY:

Definitions, key methods, and applications of computational modeling to trauma and sepsis are reviewed.

CONCLUSIONS:

Computational modeling of inflammation and organ dysfunction at the cellular, organ, whole-organism, and population levels has suggested a positive feedback cycle of inflammation → damage → inflammation that manifests via organ-specific inflammatory switching networks. This structure may manifest as multicompartment "tipping points" that drive multiple organ dysfunction. This process may be amenable to rational inflammation reprogramming.

PMID:
23863232
PMCID:
PMC3722589
DOI:
10.1097/CCM.0b013e31829a6eb4
[Indexed for MEDLINE]
Free PMC Article
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