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Transcription. 2013 Jul-Aug;4(4):162-6. Epub 2013 Jul 1.

Divergent RNA transcription: a role in promoter unwinding?

Author information

1
MRC Human Genetics Unit; Institute of Genetics and Molecular Medicine; The University of Edinburgh; Edinburgh, UK.

Abstract

New approaches using biotinylated-psoralen as a probe for investigating DNA structure have revealed new insights into the relationship between DNA supercoiling, transcription and chromatin compaction. We explore a hypothesis that divergent RNA transcription generates negative supercoiling at promoters facilitating initiation complex formation and subsequent promoter clearance.

KEYWORDS:

DNA; anti-sense RNA; chromatin; supercoiling; transcription

PMID:
23863199
PMCID:
PMC3977915
[Indexed for MEDLINE]
Free PMC Article

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