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Biomed Res Int. 2013;2013:943505. doi: 10.1155/2013/943505. Epub 2013 Jun 5.

Lipoprotein(a) serum levels in diabetic patients with retinopathy.

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1
International Ph D Program in Neuropharmacology, University of Catania, 95123 Catania, Italy. m.malaguarnera@email.it

Abstract

BACKGROUND:

Atherogenic lipoproteins, such as total cholesterol, LDL cholesterol, oxidized low density lipoprotein, and triglycerides, are associated with progression of retinopathy. Aim. To evaluate the relationship between lipoprotein(a) and retinopathy in patients with type 2 diabetes mellitus.

MATERIALS AND METHODS:

We enrolled 145 diabetic consecutive patients (82 females, 63 males; mean age 66.8 ± 12 years, mean duration of diabetes 9.4 ± 6.8 years). Presence and severity of retinopathy were evaluated. Serum lipid profile, including Lp(a) level, was assessed.

RESULTS:

High Lp(a) levels have been observed in 54 (78.3%) subjects and normal levels in 13 (18.85%) subjects as regards diabetic patients with retinopathy. Lp(a) levels were high in 15 subjects (21.75%) and normal in 63 subjects (91.35%) as regards patients without retinopathy.

CONCLUSIONS:

Lp(a) levels are increased in a significant percentage of patients with retinopathy compared to diabetic patients without retinopathy. The impact of Lp(a) levels on diabetic retinopathy needs to be further investigated.

PMID:
23862162
PMCID:
PMC3687764
DOI:
10.1155/2013/943505
[Indexed for MEDLINE]
Free PMC Article
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