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Ann Coloproctol. 2013 Jun;29(3):130-4. doi: 10.3393/ac.2013.29.3.130. Epub 2013 Jun 30.

Mucosal schwann-cell hamartoma diagnosed by using an endoscopic snare polypectomy.

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Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea.


Colorectal polyps of mesenchymal origin are a rare group of colorectal disorders. A "mucosal Schwann-cell hamartoma," which is one type of polypoid lesion that originates from the mesenchyme, is a newly-proposed disease entity to be distinguished from the neurofibromas found in type-1 neurofibromatosis. This lesion is composed of pure Schwann-cell proliferation in the lamina propria and shows diffuse immunoreactivity for the S-100 protein. We report a case of a polypoid lesion of the colon with the features of this recently-proposed disease entity.


Colon polyps; Hamartoma; Neurofibroma; Neuroma; Schwann cells

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