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J Cent Nerv Syst Dis. 2010 May 4;2:9-14. Print 2010.

Decreased Serum Cu/Zn SOD Associated with High Copper in Children with Attention Deficit Hyperactivity Disorder (ADHD).

Author information

1
Research Director, Health Research Institute/Pfeiffer Treatment Center, 4575 Weaver Parkway, Warrenville, Illinois 60555, USA. Email: ajrusso@hriptc.org.

Abstract

AIM:

To assess serum Cu/Zn SOD (Superoxide Dismutase) concentration in children with ADHD and evaluate its possible relationship to Cu and Zn levels.

SUBJECTS AND METHODS:

Serum from 22 children with ADHD and 20 healthy control children without ADHD and 19 autistic children without ADHD were tested for Cu/Zn SOD using ELISAs and levels of serum Cu and Zn using inductively-coupled plasma-mass spectrometry.

RESULTS:

Serum Cu/Zn SOD levels of ADHD children were significantly lower than age and gender matched healthy non-ADHD controls (P < 0.001). Serum Cu/Zn SOD of ADHD children was significantly lower in individuals with high serum copper (P = 0.024). There was no significant correlation between Cu/Zn SOD levels and Zinc or Cu/Zn in ADHD individuals.

DISCUSSION:

These results suggest an association between Cu/Zn SOD serum levels and ADHD, particularly ADHD children with high serum copper.

KEYWORDS:

ADHD; Cu/Zn SOD; copper; super oxide dismutase

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