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Ophthalmol Eye Dis. 2010 Nov 30;2:69-73. doi: 10.4137/OED.S5612. Print 2010.

Isolated bilateral trigeminal neuropathy in sarcoidosis presenting with neurotrophic corneal ulcers.

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Ophthalmology Department, Princess Alexandra Eye Pavilion, Edinburgh, UK.


Sarcoidosis is a multisystem granulomatous disease that may affect various organs. Nevertheless, involvement of the trigeminal nerve is exceedingly uncommon. This report presents a rare case of isolated bilateral trigeminal neuropathy presenting with neurotrophic corneal ulcers. The patient was treated with topical chloramphenicol and lubricants, as well as botulinum toxin injection to the upper eyelid to induce ptosis. Our case illustrates the importance of recognizing that bilateral corneal ulceration might be a manifestation of sarcoidosis. Physicians should be aware of this rare association, when treating sarcoidosis patients with eye related symptoms.


neurotrophic ulcers; sarcoidosis; trigeminal neuropathy

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