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Clin Neurophysiol. 2014 Jan;125(1):13-20. doi: 10.1016/j.clinph.2013.06.023. Epub 2013 Jul 13.

Permutation entropy of scalp EEG: a tool to investigate epilepsies: suggestions from absence epilepsies.

Author information

1
Magna Græcia University, Catanzaro, Italy; Regional Epilepsy Centre, "Bianchi-Melacrino-Morelli" Hospital, Reggio Calabria, Italy.
2
University Mediterranea of Reggio Calabria, Italy.
3
Regional Epilepsy Centre, "Bianchi-Melacrino-Morelli" Hospital, Reggio Calabria, Italy.
4
Magna Græcia University, Catanzaro, Italy; National Research Council, Piano Lago di Mangone, Cosenza, Italy.
5
Magna Græcia University, Catanzaro, Italy.
6
Institute of Neurology, University of Catania, Italy.
7
Unit of Neurology and Clinical Neurophysiopathology, Oasi Institute for Research on Mental Retardation and Brain Aging (IRCCS), Troina, Enna, Italy.
8
Magna Græcia University, Catanzaro, Italy; Regional Epilepsy Centre, "Bianchi-Melacrino-Morelli" Hospital, Reggio Calabria, Italy. Electronic address: u.aguglia@tin.it.

Abstract

OBJECTIVE:

We used permutation entropy (PE) to disclose abnormalities of cerebral activity in patients with typical absences (TAs).

METHODS:

We evaluated 24 EEG of TA patients and 40 EEG of healthy subjects. PE was estimated channel by channel, with electrodes being divided into high-PE cluster (high randomness), low-PE cluster (low randomness), and neutral cluster. We compared PE between EEG of patients and controls, and between interictal and ictal EEG of patients.

RESULTS:

Patients showed a recurrent behavior of PE topography, with anterior brain regions constantly associated to high PE levels and posterior brain regions constantly associated to low PE levels, during both interictal and ictal phases. On the contrary, healthy controls had a random distribution of PE topography.

CONCLUSIONS:

In patients with TAs, a higher randomness in fronto-temporal areas and a lower randomness in posterior areas occur during both interictal and ictal phases. Such abnormalities are in keeping with evidences from different morphological and functional studies showing multifocal brain changes in TA patients.

SIGNIFICANCE:

PE seems to be a useful tool to disclose abnormalities of cerebral electric activity not revealed by conventional EEG recordings, opening interesting prospective for future studies.

KEYWORDS:

Absences; Brain topography; EEG; Permutation entropy

PMID:
23859939
DOI:
10.1016/j.clinph.2013.06.023
[Indexed for MEDLINE]

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