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Prev Med. 2013 Nov;57(5):505-10. doi: 10.1016/j.ypmed.2013.07.003. Epub 2013 Jul 13.

Alcohol consumption and risk of stroke and coronary heart disease among Japanese women: the Japan Public Health Center-based prospective study.

Author information

1
Public Health, Department of Social and Environmental Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan.

Abstract

OBJECTIVE:

The study aims to examine the association between a wide range of alcohol consumption and risk of stroke and coronary heart disease.

METHODS:

The Japan Public Health Center-based prospective study was initiated in 1990 in Cohort I and in 1993 in Cohort II, with follow-up until 2009. The sample consisted of 47,100 women aged 40-69 years.

RESULTS:

During an average of 16.7-years, the incidence of 1846 strokes and 292 coronary heart diseases was observed. Heavy drinking (≥ 300 gethanol/week) was associated with increased risk of total stroke. The multivariable hazard ratios for heavy versus occasional drinkers were 2.19 (95% confidence interval: 1.45-3.30) for total stroke, 2.25 (1.29-3.91) for hemorrhagic stroke, 2.24 (1.05-4.76) for intraparenchymal hemorrhage, 2.26 (1.01-5.09) for subarachnoid hemorrhage and 2.04 (1.09-3.82) for ischemic stroke. In the exposure-updated analysis, the positive association between heavy drinking and risks of total stroke, hemorrhagic stroke and intraparenchymal hemorrhage became more evident. Light drinking (<150 gethanol/week) was not associated with risk of ischemic stroke. There was also no association between alcohol consumption and risk of coronary heart disease.

CONCLUSION:

Heavy drinking was associated with increased risk of hemorrhagic and ischemic strokes among Japanese women.

KEYWORDS:

Alcohol consumption; Coronary heart disease; Follow-up study; Incidence; Stroke

PMID:
23859928
DOI:
10.1016/j.ypmed.2013.07.003
[Indexed for MEDLINE]

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