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Sex Transm Dis. 2013 Aug;40(8):645-6. doi: 10.1097/01.OLQ.0000431351.50346.20.

Polyostotic osteitis in secondary syphilis in an HIV-infected patient.

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Unidad de Enfermedades Infecciosas, Hospital General Universitario de Alicante, Alicante, Spain.


We herein describe a case of secondary syphilis in a patient with HIV infection that presented with an unusually diffuse polyostotic osteitis with skull involvement. Syphilis has to be added to the differential diagnosis of extensive inflammatory bone pain in patients at risk, especially if pain worsens at night.

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