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Genet Test Mol Biomarkers. 2013 Oct;17(10):736-42. doi: 10.1089/gtmb.2013.0080. Epub 2013 Jul 16.

Genetic associations with hypertension: meta-analyses of six candidate genetic variants.

Author information

1
1 Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University , Ningbo, Zhejiang, China .

Abstract

AIMS:

The aim of this study was to perform combined analyses of six genetic variants for the risk of hypertension.

METHODS:

After a comprehensive literature search for genetic variants involved with the association study of hypertension, we harvested a total of five genes (six variants) for the current meta-analyses. These genes consisted of CYP4A11 (T8590C), RGS2 (1891-1892del TC and G638A), HTR2A (T102C), GNAS (T393C), and HSD3B1 (T→C Leu338).

RESULTS:

A total of 20 studies among 13,816 cases and 19,248 controls were retrieved for the meta-analyses of six genetic variants. It was shown that the RGS2 1891-1892del TC (OR=1.10, 95% CI=1.02-1.19, p=0.02) polymorphism and the CYP4A11 T8590C (OR=1.19, 95% CI=1.00-1.41, p=0.05) polymorphism were significantly associated with increased risk of hypertension. No association was found between the other four variants and the risk of hypertension.

CONCLUSION:

This meta-analysis revealed that the RGS2 1891-1892del TC polymorphism and CYP4A11 T8590C polymorphism were associated with hypertension risk. However, HSD3B1 T→C Leu338, HTR2A T102C, GNAS T393C, and RGS2 G638A polymorphisms were not associated with hypertension risk.

PMID:
23859711
PMCID:
PMC3780324
DOI:
10.1089/gtmb.2013.0080
[Indexed for MEDLINE]
Free PMC Article

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