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Curr Drug Deliv. 2014;11(2):155-71.

Solid dispersion in pharmaceutical drug development: from basics to clinical applications.

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1
Department of Pharmaceutics, College of Pharmacy, IPS Academy, Indore (M.P.) India. dineshdops@yahoo.com.

Abstract

The solubility of drugs is one of the most challenging aspects in developing formulations for novel drug discovery. Myriad of approaches have been developed and tested to overcome the associated intricacies involved with poor water soluble drugs. Out of the available technologies, solid dispersion (SD) method that significantly enhances the solubility and bioavailability by reducing particle size to a micro-molecular level is often viewed as a promising strategy. Although conceptual basis of manufacturing processes involved in SD method have been reported, formulation characteristics addressing solubility issues remains yet elusive. The current review portray the historical milestones, classification, probable mechanisms for enhancement of solubility, manufacturing processes at commercial level along with pioneer breakthroughs in field that enunciates the versatile pharmaceutical application for categories including anti-cancer and anti-retroviral drugs. Besides, our article also highlights the translational implications of drug development by SD method hitherto unreported.

PMID:
23859356
[Indexed for MEDLINE]
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