Format

Send to

Choose Destination
See comment in PubMed Commons below

[Advances of researches on caspases in neurodegenerative diseases].

[Article in Chinese]

Author information

1
Department of Chemistry and Life Science, Suzhou University, Suzhou 234000, China.

Abstract

Acute and chronic neurodegenerative diseases are illnesses associated with high morbidity and mortality, and few or no effective options are available for their treatments. Many neurodegenerative diseases are included in them, for example, stroke, brain trauma, spinal cord injury, amyotrophic lateral sclerosis (ALS), Huntington's disease, Alzheimer's disease, and Parkinson's disease. Given that central nervous system tissue has very limited, if any, regenerative capacity, it is of utmost importance to limit the damage caused by neuronal death. During the past decade, considerable progress has been made in understanding the process of cell death. In this article, we review the causes and mechanisms of neuronal-cell death, especially as it pertains to the caspases family of proteases associated with cell death. The results may be helpful to the experimental research and clinical application of neurodegenerative diseases.

PMID:
23858776
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center