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Stem Cells. 2013 Sep;31(9):1992-2002. doi: 10.1002/stem.1459.

Airway basal cells of healthy smokers express an embryonic stem cell signature relevant to lung cancer.

Author information

1
Department of Genetic Medicine, Weill Cornell Medical College, New York, New York.

Abstract

Activation of the human embryonic stem cell (hESC) signature genes has been observed in various epithelial cancers. In this study, we found that the hESC signature is selectively induced in the airway basal stem/progenitor cell population of healthy smokers (BC-S), with a pattern similar to that activated in all major types of human lung cancer. We further identified a subset of 6 BC-S hESC genes, whose coherent overexpression in lung adenocarcinoma (AdCa) was associated with reduced lung function, poorer differentiation grade, more advanced tumor stage, remarkably shorter survival, and higher frequency of TP53 mutations. BC-S shared with hESC and a considerable subset of lung carcinomas a common TP53 inactivation molecular pattern which strongly correlated with the BC-S hESC gene expression. These data provide transcriptome-based evidence that smoking-induced reprogramming of airway BC toward the hESC-like phenotype might represent a common early molecular event in the development of aggressive lung carcinomas in humans.

KEYWORDS:

Airway epithelium; Basal cells; Gene expression; Lung cancer; Stem cells

PMID:
23857717
PMCID:
PMC4051142
DOI:
10.1002/stem.1459
[Indexed for MEDLINE]
Free PMC Article

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