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Nutrients. 2013 Jul 5;5(7):2502-21. doi: 10.3390/nu5072502.

Vitamin D and immune function.

Author information

1
Division of Endocrinology and Metabolism, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, A 8036 Graz, Austria. barbara.prietl@medunigraz.at

Abstract

Vitamin D metabolizing enzymes and vitamin D receptors are present in many cell types including various immune cells such as antigen-presenting-cells, T cells, B cells and monocytes. In vitro data show that, in addition to modulating innate immune cells, vitamin D also promotes a more tolerogenic immunological status. In vivo data from animals and from human vitamin D supplementation studies have shown beneficial effects of vitamin D on immune function, in particular in the context of autoimmunity. In this review, currently available data are summarized to give an overview of the effects of vitamin D on the immune system in general and on the regulation of inflammatory responses, as well as regulatory mechanisms connected to autoimmune diseases particularly in type 1 diabetes mellitus.

PMID:
23857223
PMCID:
PMC3738984
DOI:
10.3390/nu5072502
[Indexed for MEDLINE]
Free PMC Article

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