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Exp Biol Med (Maywood). 2013 May;238(5):442-9. doi: 10.1177/1535370213480696.

Peptide and protein-based inhibitors of HIV-1 co-receptors.

Author information

1
Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.

Abstract

Human immunodeficiency virus (HIV) afflicts an estimated 30 million people globally, making it a continuing pandemic. Despite major research efforts, the rate of new infections has remained relatively static over time. This article reviews an emerging strategy for the treatment of HIV, the inhibition of the co-receptors necessary for HIV entry, CCR5 and CXCR4. The aim of this article is to highlight potential therapeutics derived from peptides and proteins that show particular promise in HIV treatment. Molecules that act on CCR5, CXCR4 or on both receptors will be discussed herein.

KEYWORDS:

CCR5; CXCR4; HIV

PMID:
23856897
PMCID:
PMC3908444
DOI:
10.1177/1535370213480696
[Indexed for MEDLINE]
Free PMC Article

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