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J Am Chem Soc. 2013 Jul 31;135(30):10994-7. doi: 10.1021/ja4066656. Epub 2013 Jul 17.

Asymmetric copper(I)-catalyzed azide-alkyne cycloaddition to quaternary oxindoles.

Author information

1
Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, East China Normal University, 3663 North Zhongshan Road, Shanghai 200062, China.

Abstract

We report a highly enantioselective Cu(I)-catalyzed azide-alkyne cycloaddition via asymmetric desymmetrization of oxindole-based 1,6-heptadiynes, which furnishes quaternary oxindoles bearing a 1,2,3-triazole-containing moiety with 84-98% ee.

PMID:
23855917
DOI:
10.1021/ja4066656

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