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Nanoscale. 2013 Sep 21;5(18):8466-71. doi: 10.1039/c3nr01251d.

Single KTP nanocrystals as second-harmonic generation biolabels in cortical neurons.

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1
Laboratoire de Physique de la Matière Condensée-Ecole Polytechnique-CNRS, UMR 7643, 91128 Palaiseau Cedex, France.

Abstract

We report an efficient colloidal synthesis of KTiOPO4 (KTP) nanocrystals with excellent crystallinity and the direct observation of optical second-harmonic generation (SHG) from discrete KTP nanocrystals in neurons cultured from mammalian brain cortex. Direct internalization and monitoring of these nanoparticles was successfully achieved without limitations from cytotoxicity, bleaching and blinking emission.

PMID:
23852161
DOI:
10.1039/c3nr01251d
[Indexed for MEDLINE]
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