The paper presents a compact planar antenna designed for wireless sensors intended for healthcare applications. Antenna performance is investigated with regards to various parameters governing the overall sensor operation. The study illustrates the importance of including full sensor details in determining and analysing the antenna performance. A globally optimized sensor antenna shows an increase in antenna gain by 2.8 dB and 29% higher radiation efficiency in comparison to a conventional printed strip antenna. The wearable sensor performance is demonstrated and effects on antenna radiated power, efficiency and front to back ratio of radiated energy are investigated both numerically and experimentally. Propagation characteristics of the body-worn sensor to on-body and off-body base units are also studied. It is demonstrated that the improved sensor antenna has an increase in transmitted and received power, consequently sensor coverage range is extended by approximately 25%.