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Retina. 2014 Feb;34(2):281-7. doi: 10.1097/IAE.0b013e3182979e33.

Intravitreal ranibizumab for choroidal neovascularization with large submacular hemorrhage in age-related macular degeneration.

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1
*G. B. Bietti Foundation for Ophthalmology, Scientific Institute of Admission and Care, Rome, Italy; and †Department of Ophthalmology, Vita-Salute San Raffaele University, Milan, Italy.

Abstract

PURPOSE:

To evaluate the effects of intravitreal ranibizumab injections in the treatment of choroidal neovascularization with large submacular hemorrhage secondary to age-related macular degeneration.

METHODS:

Prospective interventional case series. Patients presenting occult choroidal neovascularization with flat large submacular hemorrhage >50% of the entire lesion were considered. The protocol required 3 monthly consecutive injections, followed by repeat injections over the 12-month follow-up on the basis of optical coherence tomography parameters and angiographic features.

RESULTS:

Twenty-three patients were enrolled in the study and prospectively followed up. Mean best-corrected visual acuity and mean central macular thickness at the baseline were 0.82 ± 0.22 (logarithm of the minimum angle of resolution ± standard deviation) and 342 ± 56 µm, respectively. At 12-month examination, mean visual acuity improved significantly to 0.68 ± 0.41 (P = 0.04), and mean central macular thickness decreased to 236 ± 26 µm (P < 0.0001). A progressive resolution of macular bleeding was registered in 22 of 23 patients. No side effect or complication was registered.

CONCLUSION:

Intravitreal ranibizumab can be considered a beneficial approach for the management of choroidal neovascularization with flat large submacular hemorrhage secondary to age-related macular degeneration.

PMID:
23851632
DOI:
10.1097/IAE.0b013e3182979e33
[Indexed for MEDLINE]
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