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Clin Oncol (R Coll Radiol). 2013 Oct;25(10):569-77. doi: 10.1016/j.clon.2013.06.009. Epub 2013 Jul 10.

The hallmarks of cancer and the radiation oncologist: updating the 5Rs of radiobiology.

Author information

1
Head and Neck Unit, The Royal Marsden Hospital, London, UK.

Abstract

A comprehensive, mechanistic understanding of radiobiological phenomena that can be integrated within the broader context of cancer biology offers the prospect of transforming clinical practice in radiation oncology. In this review, we revisit the six established biological hallmarks of cancer and examine how they have provided insights into novel therapeutic strategies. In addition, we discuss the potential of two emerging hallmarks to continue to expand our understanding beyond the narrow confines of the traditional 5Rs of radiobiology.

KEYWORDS:

Radiobiology; radiosensitivity; redistribution; reoxygenation; repair; repopulation

PMID:
23850153
DOI:
10.1016/j.clon.2013.06.009
[Indexed for MEDLINE]

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