Format

Send to

Choose Destination
See comment in PubMed Commons below
J Headache Pain. 2013 Jul 12;14:61. doi: 10.1186/1129-2377-14-61.

Genes and primary headaches: discovering new potential therapeutic targets.

Author information

1
Headache Center, Neurology I, Department of Neuroscience, University of Torino, Via Cherasco 15, Torino 10126, Italy. innocenzo.rainero@unito.it

Abstract

Genetic studies have clearly shown that primary headaches (migraine, tension-type headache and cluster headache) are multifactorial disorders characterized by a complex interaction between different genes and environmental factors. Genetic association studies have highlighted a potential role in the etiopathogenesis of these disorders for several genes related to vascular, neuronal and neuroendocrine functions. A potential role as a therapeutic target is now emerging for some of these genes. The main purpose of this review is to describe new advances in our knowledge regarding the role of MTHFR, KCNK18, TRPV1, TRPV3 and HCRTR genes in primary headache disorders. Involvement of these genes in primary headaches, as well as their potential role in the therapy of these disorders, will be discussed.

PMID:
23848401
PMCID:
PMC3716727
DOI:
10.1186/1129-2377-14-61
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer Icon for PubMed Central
    Loading ...
    Support Center