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Gan To Kagaku Ryoho. 2013 Apr;40(4):419-23.

[Cancer stem cells depend on their own niche].

[Article in Japanese]

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Dept. of Surgery, Graduate School of Medicine, Osaka University, Suita, Japan.


It is considered that cancer stem cells have the same characteristics as normal stem cells, such as drug-resistance, self-renewal, differentiation, and tissue-formation. Normal stem cells depend on their surroundings, a niche. Cancer stem cells may also depend on their own niche. Because cancer stem cells are resistant to present remedies, it is important to find a remedy targeting cancer stem cells. The remedy must not only target cancer stem cells themselves but also target the niche surrounding the cancer stem cells.

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