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Histochem Cell Biol. 2013 Sep;140(3):251-60. doi: 10.1007/s00418-013-1124-7. Epub 2013 Jul 12.

The many routes of Golgi-dependent trafficking.

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Institut Curie, Paris, France.


The Golgi apparatus lies at the center of intracellular trafficking, controlling secretory and retrograde routes. Its role is essential both to ensure housekeeping cellular functions and to sustain highly differentiated ones. While Golgi dynamics and function have been studied by many groups for several decades now, and intensely for more than 40 years, the mechanisms of Golgi-dependent secretion, how anterograde and retrograde intra-Golgi transports are controlled, as well as the regulation of the Golgi stacked structure and function are some of the many questions that are still open. We will review here the main characteristics of intra-Golgi trafficking discuss the different models that were built to explain the diversity of intra-Golgi routes and its dynamics and propose an integrative model.

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