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Chem Commun (Camb). 2013 Aug 25;49(66):7286-8. doi: 10.1039/c3cc43334j.

Morpholino-decorated long circulating polymeric micelles with the function of surface charge transition triggered by pH changes.

Author information

1
Key Laboratory of Functional Polymer Materials (Ministry of Education), Institute of Polymer Chemistry, Nankai University, Tianjin 300071, China.

Abstract

Micelles with surface morpholino groups were stealthy at blood and normal tissue pH (7.4) due to the unprotonated hydrophilic morpholino groups on the surfaces. At tumor pH (<7), the micelle surfaces were positively charged because of the protonation of the morpholino groups, which promoted the cellular uptake of the micelles.

PMID:
23846234
DOI:
10.1039/c3cc43334j
[Indexed for MEDLINE]

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