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Cancer Cell. 2013 Jul 8;24(1):3-5. doi: 10.1016/j.ccr.2013.06.010.

Par(-4)oxysm in breast cancer.

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1
Graduate Center for Toxicology, University of Kentucky, Lexington, KY 40508, USA.

Abstract

Women suffering from breast cancer often succumb to incurable recurrent disease resulting from therapy-resistant cancer cells. In this issue of Cancer Cell, Alvarez and colleagues identify downregulation of the tumor suppressor Par-4 as the key determinant in apoptosis evasion, which leads to tumor recurrence in breast cancer.

PMID:
23845436
PMCID:
PMC3743248
DOI:
10.1016/j.ccr.2013.06.010
[Indexed for MEDLINE]
Free PMC Article
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