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Am J Neurodegener Dis. 2013 Jun 21;2(2):89-107. Print 2013.

Immunity and inflammation in neurodegenerative diseases.

Author information

1
Interdisciplinary Research Center of Autoimmune Diseases (IRCAD), University of Eastern Piedmont, "Amedeo Avogadro" Novara, Italy ; Department of Health Sciences, University of Eastern Piedmont, "Amedeo Avogadro" Novara, Italy.

Abstract

Immune reactions inside the central nervous system are finely regulated, thanks to the presence of several checkpoints that have the fundamental purpose to preserve this fragile tissue form harmful events. The current knowledge on the role of neuroinflammation and neuro-immune interactions in the fields of multiple sclerosis, Alzheimer's disease and Parkinson's disease is reviewed. Moreover, a focus on the potential role of both active and passive immunotherapy is provided. Finally, we propose a common perspective, which implies that, under pathological conditions, inflammation may exert both detrimental and protective functions, depending on local factors and the timing of immune activation and shutting-off systems.

KEYWORDS:

Alzheimer’s disease; Multiple sclerosis; Parkinsons disease; neuro-immnue interactions; neuroinflammation

PMID:
23844334
PMCID:
PMC3703122
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