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Evid Based Complement Alternat Med. 2013;2013:306705. doi: 10.1155/2013/306705. Epub 2013 Jun 16.

The inhibitory effect of ellagic Acid on cell growth of ovarian carcinoma cells.

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1
Department of Surgery, Cheng-Ching Hospital, Chung-Kang Branch, No. 118, Section 3, Chung Kang Road, Taichung City 40764, Taiwan.

Abstract

Ellagic acid (EA) is able to inhibit the growth of several cancer cells; however, its effect on human ovarian carcinoma cells has not yet been investigated. Ovarian carcinoma ES-2 and PA-1 cells were treated with EA (10~100  μ M) and assessed for viability, cell cycle, apoptosis, anoikis, autophagy, and chemosensitivity to doxorubicin and their molecular mechanisms. EA inhibited cell proliferation in a dose- and time-dependent manner by arresting both cell lines at the G1 phase of the cell cycle, which were from elevating p53 and Cip1/p21 and decreasing cyclin D1 and E levels. EA also induced caspase-3-mediated apoptosis by increasing the Bax : Bcl-2 ratio and restored anoikis in both cell lines. The enhancement of apoptosis and/or inhibition of autophagy in these cells by EA assisted the chemotherapy efficacy. The results indicated that EA is a potential novel chemoprevention and treatment assistant agent for human ovarian carcinoma.

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