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Mediators Inflamm. 2013;2013:342931. doi: 10.1155/2013/342931. Epub 2013 Jun 15.

Innate immunity and neuroinflammation.

Author information

1
Centre for Infection, Immunity and Disease Mechanisms, Heinz Wolff Building, Brunel University, London UB8 3PH, UK.

Abstract

Inflammation of central nervous system (CNS) is usually associated with trauma and infection. Neuroinflammation occurs in close relation to trauma, infection, and neurodegenerative diseases. Low-level neuroinflammation is considered to have beneficial effects whereas chronic neuroinflammation can be harmful. Innate immune system consisting of pattern-recognition receptors, macrophages, and complement system plays a key role in CNS homeostasis following injury and infection. Here, we discuss how innate immune components can also contribute to neuroinflammation and neurodegeneration.

PMID:
23843682
PMCID:
PMC3697414
DOI:
10.1155/2013/342931
[Indexed for MEDLINE]
Free PMC Article

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