Format

Send to

Choose Destination
See comment in PubMed Commons below
Chembiochem. 2013 Aug 19;14(12):1444-9. doi: 10.1002/cbic.201300143. Epub 2013 Jul 10.

Unusual tubulin-clustering ability of specifically c7-modified colchicine analogues.

Author information

1
M. V. Lomonosov Moscow State University, Leninskie Gory, 119992 Moscow, Russian Federation.

Abstract

Highly cytotoxic C7-modified colchicine analogues, exemplified by tubuloclustin, promote microtubule disassembly followed by the formation of very stable tubulin clusters, both in vitro and in cells. The proposed mechanism of action of tubuloclustin and its analogues, beyond that of colchicine, includes additional specific interactions with the α-tubulin subunit.

KEYWORDS:

anticancer agents; apoptosis; colchicine; cytotoxicity; microtubules; tubulin

PMID:
23843347
DOI:
10.1002/cbic.201300143
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Support Center